Topical cholesterol treatment of recessive X-linked ichthyosis

Lancet. 1983 Dec 10;2(8363):1337-8. doi: 10.1016/s0140-6736(83)91093-0.

Abstract

In an open prospective half-side trial, creams containing 10% cholesterol or 10% urea were applied to lesions in 20 steroid-sulphatase-deficient male patients with recessive X-linked ichthyosis. In 18 there was a good response to the cholesterol cream. In 13 patients the response to cholesterol was better than that to urea. None showed a better response to urea than to cholesterol. A reduction in the cholesterol content of the stratum corneum may be responsible for abnormal cornification in recessive X-linked ichthyosis.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Cholesterol / administration & dosage*
  • Cholesterol Esters / administration & dosage
  • Clinical Trials as Topic
  • Genes, Recessive
  • Genetic Linkage
  • Humans
  • Ichthyosis / drug therapy*
  • Ichthyosis / genetics
  • Infant
  • Male
  • Prospective Studies

Substances

  • Cholesterol Esters
  • Cholesterol
  • cholesteryl sulfate