Aetiology of Parkinson's disease

Lancet. 1983 Dec 24-31;2(8365-66):1457-9. doi: 10.1016/s0140-6736(83)90802-4.

Abstract

It is suggested here that in most cases of Parkinson's disease the cause may be an environmental factor, possibly toxic, superimposed on a background of slow, sustained neuronal loss due to advancing age.

MeSH terms

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Aging
  • Animals
  • Diseases in Twins
  • Environmental Exposure
  • Humans
  • Models, Neurological
  • Neurotoxins / poisoning
  • Parkinson Disease / etiology*
  • Parkinson Disease / genetics
  • Pyridines / poisoning
  • Virus Diseases / complications

Substances

  • Neurotoxins
  • Pyridines
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine