Abstract
The use of cimetidine, the histamine H2 receptor antagonist, is associated with a relatively low incidence of adverse reactions. However, its liberal use has led to the identification of several clinically significant cimetidine-drug interactions that can lead to drug accumulation, toxicity, and life-threatening sequelae. A review of the literature and the clinical significance and physiologic basis of these interactions are presented. Recommended management of cimetidine-drug interactions is discussed.
MeSH terms
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Adrenergic beta-Antagonists / metabolism
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Anticonvulsants / metabolism
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Benzodiazepines / metabolism
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Chlormethiazole / metabolism
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Cimetidine / adverse effects*
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Cimetidine / pharmacology
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Drug Interactions
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Humans
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Ketoconazole / metabolism
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Kidney / drug effects
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Lidocaine / metabolism
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Morphine / metabolism
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Penicillins / metabolism
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Theophylline / metabolism
Substances
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Adrenergic beta-Antagonists
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Anticonvulsants
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Penicillins
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Chlormethiazole
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Benzodiazepines
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Morphine
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Cimetidine
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Lidocaine
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Theophylline
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Ketoconazole