Family history and CSF homovanillic acid pattern during neuroleptic treatment

Am J Psychiatry. 1984 Feb;141(2):296-8. doi: 10.1176/ajp.141.2.296.

Abstract

In 24 patients receiving neuroleptics, the 11 patients whose CSF homovanillic acid showed no tolerance to neuroleptics at 1 month had significantly more residual symptoms, extrapyramidal side effects, and history of psychiatric hospitalization in first-degree relatives.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antipsychotic Agents / therapeutic use*
  • Basal Ganglia Diseases / chemically induced
  • Female
  • Homovanillic Acid / cerebrospinal fluid*
  • Hospitalization
  • Hospitals, Psychiatric
  • Humans
  • Male
  • Mental Disorders / genetics*
  • Parkinson Disease, Secondary / chemically induced
  • Phenylacetates / cerebrospinal fluid*
  • Prognosis
  • Psychotic Disorders / cerebrospinal fluid
  • Psychotic Disorders / drug therapy*
  • Psychotic Disorders / psychology

Substances

  • Antipsychotic Agents
  • Phenylacetates
  • Homovanillic Acid