New concepts in benzodiazepine therapy: rebound anxiety and new indications for the more potent benzodiazepines

Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):669-73. doi: 10.1016/0278-5846(83)90043-x.


Abrupt withdrawal of benzodiazepine treatment in generalized anxiety patients was found to induce a rebound anxiety state in addition to minor physical symptoms. Controlled clinical trials suggest that the newer high potency benzodiazepines (alprazolam, clonazepam and bromazepam) have novel psychiatric indications and greater anxiolytic effect than the classical benzodiazepines. Alprazolam, a triazolobenzodiazepine, was superior to placebo in the treatment of panic disorder, for which medium or low potency benzodiazepines are generally inefficacious. Clonazepam, an anticonvulsant which increases 5HT synthesis, was more efficacious than lithium in reducing manic symptoms. Bromazepam, a new potent benzodiazepine, was superior to diazepam in the treatment of generalized anxiety disorder.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Alprazolam
  • Anti-Anxiety Agents / therapeutic use*
  • Anxiety Disorders / drug therapy*
  • Anxiety Disorders / psychology
  • Benzodiazepines / therapeutic use
  • Bipolar Disorder / drug therapy
  • Bromazepam / therapeutic use
  • Clinical Trials as Topic
  • Clonazepam / therapeutic use
  • Diazepam / therapeutic use
  • Humans
  • Panic / drug effects
  • Receptors, Cell Surface / drug effects
  • Receptors, GABA-A
  • Recurrence
  • Substance Withdrawal Syndrome / drug therapy


  • Anti-Anxiety Agents
  • Receptors, Cell Surface
  • Receptors, GABA-A
  • Benzodiazepines
  • Clonazepam
  • Diazepam
  • Bromazepam
  • Alprazolam