Abstract
The adenosine agonist 2-chloroadenosine inhibited the K+-induced release of endogenously synthesized [3H]glutamate but not [3H]GABA from slices of rat dentate gyrus. In contrast, the K+-stimulated release of [3H]glutamate was augmented by the adenosine antagonist theophylline and was further enhanced by the cyclic AMP analogue 8-bromo-cyclic AMP in the presence of theophylline.
MeSH terms
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2-Chloroadenosine
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8-Bromo Cyclic Adenosine Monophosphate / pharmacology*
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Adenosine / analogs & derivatives*
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Adenosine / pharmacology
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Animals
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Glutamates / metabolism*
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Glutamic Acid
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Hippocampus / drug effects
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Hippocampus / metabolism*
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In Vitro Techniques
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Kinetics
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Male
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Potassium / pharmacology
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Rats
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Theophylline / pharmacology*
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gamma-Aminobutyric Acid / metabolism*
Substances
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Glutamates
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2-Chloroadenosine
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8-Bromo Cyclic Adenosine Monophosphate
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Glutamic Acid
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gamma-Aminobutyric Acid
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Theophylline
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Adenosine
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Potassium