An adenosine agonist inhibits and a cyclic AMP analogue enhances the release of glutamate but not GABA from slices of rat dentate gyrus

Neurosci Lett. 1983 Dec 23;43(1):49-54. doi: 10.1016/0304-3940(83)90127-1.

Abstract

The adenosine agonist 2-chloroadenosine inhibited the K+-induced release of endogenously synthesized [3H]glutamate but not [3H]GABA from slices of rat dentate gyrus. In contrast, the K+-stimulated release of [3H]glutamate was augmented by the adenosine antagonist theophylline and was further enhanced by the cyclic AMP analogue 8-bromo-cyclic AMP in the presence of theophylline.

MeSH terms

  • 2-Chloroadenosine
  • 8-Bromo Cyclic Adenosine Monophosphate / pharmacology*
  • Adenosine / analogs & derivatives*
  • Adenosine / pharmacology
  • Animals
  • Glutamates / metabolism*
  • Glutamic Acid
  • Hippocampus / drug effects
  • Hippocampus / metabolism*
  • In Vitro Techniques
  • Kinetics
  • Male
  • Potassium / pharmacology
  • Rats
  • Theophylline / pharmacology*
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • Glutamates
  • 2-Chloroadenosine
  • 8-Bromo Cyclic Adenosine Monophosphate
  • Glutamic Acid
  • gamma-Aminobutyric Acid
  • Theophylline
  • Adenosine
  • Potassium