Fluctuating islet-cell autoimmunity in unaffected relatives of patients with insulin-dependent diabetes

Lancet. 1984 Apr 7;1(8380):764-6. doi: 10.1016/s0140-6736(84)91278-9.

Abstract

Complement-fixing islet-cell antibodies (CF-ICA) were found in 20 out of 685 unaffected first-degree relatives of children with type 1 diabetes. During a 5-year follow-up, 7 of the 20 became diabetic, 1 continued to show the antibodies without any abnormality of glucose tolerance, and 12 subjects lost them without the disease developing. Although CF-ICA are useful as a marker of active insulitis they should not at present be used to define subjects who might benefit from preventive immunosuppression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies / analysis*
  • Autoimmune Diseases / genetics*
  • Complement Fixation Tests
  • Diabetes Mellitus, Type 1 / genetics*
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / therapy
  • Disease Susceptibility
  • Environment
  • Follow-Up Studies
  • Genotype
  • Glucose Tolerance Test
  • HLA Antigens / genetics
  • HLA Antigens / immunology
  • Histocompatibility Antigens Class II / immunology
  • Humans
  • Immunosuppression
  • Islets of Langerhans / immunology*
  • Islets of Langerhans / microbiology
  • Prospective Studies

Substances

  • Antibodies
  • HLA Antigens
  • Histocompatibility Antigens Class II