Neuromedin L: a novel mammalian tachykinin identified in porcine spinal cord

Neuropeptides. 1984 Mar;4(2):157-66. doi: 10.1016/0143-4179(84)90126-4.

Abstract

A novel mammalian tachykinin, designated "neuromedin L", has been isolated from porcine spinal cord by using bioassay for a tachykinin-like effect on contractility of smooth muscle preparation from guinea pig ileum. By microsequencing, the peptide has been determined to be His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2. This structure has been confirmed by synthesis. Neuromedin L is found to elicit a prompt stimulant activity on guinea pig ileum in a manner similar to that of substance P, and to have remarkable sequence homology to kassinin as well as neuromedin K, which we have recently identified as a mammalian tachykinin. These facts suggest that neuromedin L may participate in neural transmission in the same manner as other members of the mammalian tachykinin family, such as substance P and neuromedin K.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Assay
  • Ileum / drug effects
  • Nerve Tissue Proteins / isolation & purification*
  • Neurokinin A
  • Neurotransmitter Agents / isolation & purification
  • Oligopeptides / isolation & purification*
  • Spinal Cord / analysis*
  • Swine

Substances

  • Nerve Tissue Proteins
  • Neurotransmitter Agents
  • Oligopeptides
  • Neurokinin A