Genetic aspects of multiple endocrine neoplasia

Annu Rev Med. 1984;35:25-31. doi: 10.1146/annurev.me.35.020184.000325.

Abstract

There are three well-delineated multiple endocrine neoplasia syndromes, all of which are inherited as autosomal dominant traits. Available evidence suggests that still more such entities exist. Despite intensive study, the nature of the genetic defect that results in these syndromes remains obscure.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Neoplasms / genetics
  • Adrenal Cortex Neoplasms / metabolism
  • Adrenal Cortex Neoplasms / surgery
  • Carcinoma / genetics
  • Carcinoma / metabolism
  • Carcinoma / surgery
  • Cell Differentiation
  • Genes, Dominant
  • Hormones, Ectopic / metabolism
  • Humans
  • Multiple Endocrine Neoplasia / etiology
  • Multiple Endocrine Neoplasia / genetics*
  • Neural Crest / cytology
  • Pheochromocytoma / genetics
  • Pheochromocytoma / metabolism
  • Pheochromocytoma / surgery
  • Syndrome
  • Thyroid Neoplasms / genetics
  • Thyroid Neoplasms / metabolism
  • Thyroid Neoplasms / surgery
  • Zollinger-Ellison Syndrome / genetics
  • Zollinger-Ellison Syndrome / metabolism
  • Zollinger-Ellison Syndrome / surgery

Substances

  • Hormones, Ectopic