Properties of acetylcholine receptors translated by cat muscle mRNA in Xenopus oocytes

EMBO J. 1982;1(11):1307-12.

Abstract

Poly(A)+ mRNA, extracted from denervated skeletal muscles of the cat, directs the synthesis of acetylcholine receptors in Xenopus laevis oocytes. The receptors are inserted in the oocyte membrane where they form acetylcholine receptor-channel complexes which have properties like those of the native receptors in the muscle membrane.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cats
  • Female
  • Muscle Denervation
  • Muscles / metabolism*
  • Oocytes / physiology*
  • Poly A / genetics
  • Protein Biosynthesis*
  • RNA, Messenger / genetics*
  • Receptors, Cholinergic / genetics*
  • Receptors, Muscarinic / physiology
  • Receptors, Nicotinic / physiology
  • Xenopus

Substances

  • RNA, Messenger
  • Receptors, Cholinergic
  • Receptors, Muscarinic
  • Receptors, Nicotinic
  • Poly A