Raised transmembrane oxalate flux in red blood cells in idiopathic calcium oxalate nephrolithiasis

Lancet. 1984 Jul 7;2(8393):12-3. doi: 10.1016/s0140-6736(84)91998-6.

Abstract

Red-blood-cell transmembrane oxalate flux was measured in a group of patients with idiopathic calcium oxalate nephrolithiasis and in normal controls. The mean transmembrane oxalate flux rate was significantly higher in stone-forming patients than in controls (0.93 +/- SD 0.31/min vs 0.29 +/- 0.11/min). 80% of stone-forming patients showed raised (greater than 2SD above the mean in controls) transmembrane oxalate flux. Anomalous cellular oxalate transport may be an important pathogenetic factor in calcium oxalate nephrolithiasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biological Transport
  • Calcium Oxalate
  • Erythrocyte Membrane / metabolism*
  • Erythrocytes / metabolism*
  • Female
  • Humans
  • Kidney Calculi / metabolism*
  • Male
  • Middle Aged
  • Oxalates / blood*

Substances

  • Oxalates
  • Calcium Oxalate