Symptoms after primary immunisation with DTP and with DT vaccine

Lancet. 1984 Jul 21;2(8395):146-9. doi: 10.1016/s0140-6736(84)91057-2.


Symptoms after routine primary immunisation of 6004 infants with diphtheria/tetanus/pertussis (DTP) vaccine and 4024 infants with diphtheria/tetanus (DT) vaccine have been compared. After each dose, crying, screaming, and feverishness were more frequent with adsorbed DTP than adsorbed DT, but the difference was small. Attacks of high-pitched screaming, episodes of pallor or cyanosis with limpness, convulsions, and local reactions occurred with similar frequency after both vaccines. There was a considerable increase in local reactions after the 3rd dose with both vaccines. Over 1000 doses of plain DTP (with no aluminium hydroxide adjuvant) were given during the study. Post-vaccination symptoms were more common after the plain than after the 2 adsorbed preparations.

Publication types

  • Comparative Study

MeSH terms

  • Crying
  • Cyanosis / etiology
  • Diphtheria Toxoid / adverse effects*
  • Diphtheria Toxoid / immunology
  • Diphtheria-Tetanus Vaccine
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Drug Combinations / adverse effects
  • Drug Combinations / immunology
  • Female
  • Humans
  • Infant
  • Male
  • Pallor / etiology
  • Pertussis Vaccine / adverse effects*
  • Pertussis Vaccine / immunology
  • Seizures / etiology
  • Sudden Infant Death / etiology
  • Tetanus Toxoid / adverse effects*
  • Tetanus Toxoid / immunology
  • Vaccination / adverse effects*


  • Diphtheria Toxoid
  • Diphtheria-Tetanus Vaccine
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Drug Combinations
  • Pertussis Vaccine
  • Tetanus Toxoid