Modulation of a central pattern generator by two neuropeptides, proctolin and FMRFamide

Brain Res. 1984 Jul 2;305(1):186-91. doi: 10.1016/0006-8993(84)91138-7.


The neuropeptides, proctolin and FMRFamide, increase the frequency of, and modify the motor pattern produced by, the stomatogastric ganglion (STG) of the crab, Cancer irroratus. Both proctolin-like and FMRFamide-like immunoreactivities are present in fibers in the stomatogastric nerve which terminate in the neuropile of the STG. The neural output of the STG thus appears to be modulated by at least two different groups of peptidergic input fibers.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brachyura / physiology*
  • FMRFamide
  • Ganglia / drug effects*
  • Ganglia / metabolism
  • In Vitro Techniques
  • Motor Neurons / drug effects
  • Neuropeptides*
  • Neurotransmitter Agents / pharmacology*
  • Oligopeptides / metabolism
  • Oligopeptides / pharmacology*
  • Stimulation, Chemical


  • Neuropeptides
  • Neurotransmitter Agents
  • Oligopeptides
  • proctolin
  • FMRFamide