The effect of the dioxolanes on amino acid induced excitation in the mammalian spinal cord

Brain Res. 1984 Jul 30;307(1-2):85-90. doi: 10.1016/0006-8993(84)90463-3.


The effects of the dissociative anaesthetic, etoxadrol, and the stereoisomers of dioxadrol, dexoxadrol and levoxadrol, were examined on the excitation of spinal neurones by electrophoretically administered amino acids in pentobarbitone- or urethane-anaesthetized rats, or pentobarbitone-anaesthetized cats. Both etoxadrol and the (+)isomer of dioxadrol, dexoxadrol, administered locally or systemically, exhibited a selective antagonism of N-methyl-D,L-aspartate relative to quisqualate and kainate. This selective antagonism was not observed with the (-)isomer of dioxadrol, levoxadrol. Since such a stereoselective antagonism of the excitation of spinal neurones by N-methyl-D,L-aspartate is also displayed by the dissociative anaesthetics phencyclidine and ketamine, it is suggested that a reduced efficiency at excitatory synapses utilising N-methyl-D,L-aspartate receptors contributes to that part of the pharmacological spectrum common to both arylcyclohexylamines and dioxolanes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aspartic Acid / analogs & derivatives*
  • Aspartic Acid / antagonists & inhibitors
  • Cats
  • Dioxolanes / pharmacology*
  • Dioxoles / pharmacology*
  • Kainic Acid / antagonists & inhibitors
  • Ketamine / pharmacology
  • N-Methylaspartate
  • Oxadiazoles / antagonists & inhibitors
  • Phencyclidine / pharmacology
  • Quisqualic Acid
  • Rats
  • Species Specificity
  • Spinal Cord / drug effects*
  • Stereoisomerism
  • Structure-Activity Relationship


  • Dioxolanes
  • Dioxoles
  • Oxadiazoles
  • Aspartic Acid
  • N-Methylaspartate
  • Ketamine
  • Quisqualic Acid
  • Phencyclidine
  • Kainic Acid