Turnover of inositol phospholipids and signal transduction

Science. 1984 Sep 21;225(4668):1365-70. doi: 10.1126/science.6147898.


Various extracellular informational signals such as those from a group of hormones and some neurotransmitters appear to be passed from the cell surface into the cell interior by two routes, protein kinase C activation and Ca2+ mobilization. Both routes usually become available as the result of an interaction of a single ligand and a receptor and act synergistically to evoke subsequent cellular responses such as release reactions. The signal-dependent breakdown of inositol phospholipids, particularly phosphatidylinositol bisphosphate, now appears to be a key event for initiating these processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / physiology*
  • Calcium / metabolism
  • Enzyme Activation
  • Nerve Tissue Proteins / metabolism
  • Neurotransmitter Agents / physiology
  • Phosphatidylinositols / metabolism*
  • Phosphoproteins / metabolism
  • Phosphorylation
  • Protein Kinase C
  • Protein Kinases / metabolism
  • Receptors, Cell Surface / physiology
  • Synaptic Transmission*
  • Tetradecanoylphorbol Acetate / pharmacology


  • Nerve Tissue Proteins
  • Neurotransmitter Agents
  • Phosphatidylinositols
  • Phosphoproteins
  • Receptors, Cell Surface
  • Protein Kinases
  • Protein Kinase C
  • Tetradecanoylphorbol Acetate
  • Calcium