Abstract
Various extracellular informational signals such as those from a group of hormones and some neurotransmitters appear to be passed from the cell surface into the cell interior by two routes, protein kinase C activation and Ca2+ mobilization. Both routes usually become available as the result of an interaction of a single ligand and a receptor and act synergistically to evoke subsequent cellular responses such as release reactions. The signal-dependent breakdown of inositol phospholipids, particularly phosphatidylinositol bisphosphate, now appears to be a key event for initiating these processes.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Brain / physiology*
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Calcium / metabolism
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Enzyme Activation
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Nerve Tissue Proteins / metabolism
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Neurotransmitter Agents / physiology
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Phosphatidylinositols / metabolism*
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Phosphoproteins / metabolism
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Phosphorylation
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Protein Kinase C
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Protein Kinases / metabolism
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Receptors, Cell Surface / physiology
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Synaptic Transmission*
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Tetradecanoylphorbol Acetate / pharmacology
Substances
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Nerve Tissue Proteins
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Neurotransmitter Agents
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Phosphatidylinositols
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Phosphoproteins
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Receptors, Cell Surface
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Protein Kinases
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Protein Kinase C
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Tetradecanoylphorbol Acetate
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Calcium