Abstract
The selective dopamine (DA) D-1 antagonist SCH 23390 antagonized the contralateral circling behaviour induced by the DA D-1 agonist SK & F 38393 in rats lesioned unilaterally with 6-hydroxy-DA but had a 600 times weaker effect against the preferential DA D-2 agonist pergolide. The D-2 antagonists clebopride and spiroperidol had the reverse selectivity. The mixed D-1/D-2 antagonists cis(Z)-flupentixol and cis(Z)-clopenthixol blocked the circling induced by either agonist. It is concluded that circling behaviour is mediated by closely related but independent DA D-1 and D-2 receptor sites.
MeSH terms
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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Amphetamine / pharmacology
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Animals
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Antipsychotic Agents / pharmacology
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Appetite Depressants / pharmacology
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Benzamides / pharmacology
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Benzazepines / pharmacology
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Catalepsy / chemically induced
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Clopenthixol / pharmacology
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Ergolines / pharmacology
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Flupenthixol / pharmacology
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Humans
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Hydroxydopamines / pharmacology*
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Male
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Oxidopamine
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Pergolide
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Rats
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Rats, Inbred Strains
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Receptors, Dopamine / drug effects*
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Stereotyped Behavior / drug effects*
Substances
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Antipsychotic Agents
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Appetite Depressants
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Benzamides
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Benzazepines
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Ergolines
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Hydroxydopamines
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Receptors, Dopamine
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Pergolide
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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Oxidopamine
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Clopenthixol
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Amphetamine
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Flupenthixol
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clebopride