Differential inhibition by dopamine D-1 and D-2 antagonists of circling behaviour induced by dopamine agonists in rats with unilateral 6-hydroxydopamine lesions

Eur J Pharmacol. 1984 Jul 13;102(2):349-54. doi: 10.1016/0014-2999(84)90267-x.

Abstract

The selective dopamine (DA) D-1 antagonist SCH 23390 antagonized the contralateral circling behaviour induced by the DA D-1 agonist SK & F 38393 in rats lesioned unilaterally with 6-hydroxy-DA but had a 600 times weaker effect against the preferential DA D-2 agonist pergolide. The D-2 antagonists clebopride and spiroperidol had the reverse selectivity. The mixed D-1/D-2 antagonists cis(Z)-flupentixol and cis(Z)-clopenthixol blocked the circling induced by either agonist. It is concluded that circling behaviour is mediated by closely related but independent DA D-1 and D-2 receptor sites.

Publication types

  • Comparative Study

MeSH terms

  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
  • Amphetamine / pharmacology
  • Animals
  • Antipsychotic Agents / pharmacology
  • Appetite Depressants / pharmacology
  • Benzamides / pharmacology
  • Benzazepines / pharmacology
  • Catalepsy / chemically induced
  • Clopenthixol / pharmacology
  • Ergolines / pharmacology
  • Flupenthixol / pharmacology
  • Humans
  • Hydroxydopamines / pharmacology*
  • Male
  • Oxidopamine
  • Pergolide
  • Rats
  • Rats, Inbred Strains
  • Receptors, Dopamine / drug effects*
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Stereotyped Behavior / drug effects*

Substances

  • Antipsychotic Agents
  • Appetite Depressants
  • Benzamides
  • Benzazepines
  • Ergolines
  • Hydroxydopamines
  • Receptors, Dopamine
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Pergolide
  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
  • Oxidopamine
  • Clopenthixol
  • Amphetamine
  • Flupenthixol
  • clebopride