Abstract
Dichloroacetate (an activator of pyruvate dehydrogenase) stimulates 14CO2 production from [U-14C]glucose, but not from [U-14C]glutamate, [U-14C]aspartate, [U-14C]- and [1-14C]-valine and [U-14C]- and [1-14C]-leucine. It is concluded (1) that pyruvate dehydrogenase is not rate-limiting in the oxidation to CO2 of amino acids that are metabolized to tricarboxylic acid-cycle intermediates, and (2) that carbohydrate (and not amino acids) is the main carbon precursor in alanine formation in muscle.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / pharmacology*
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Alanine / metabolism*
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Amino Acids / metabolism*
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Animals
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Aspartic Acid / metabolism
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Diaphragm / metabolism
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Dichloroacetic Acid / pharmacology*
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Glucose / metabolism
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Glutamates / metabolism
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Glutamic Acid
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In Vitro Techniques
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Male
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Muscles / drug effects
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Muscles / metabolism*
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Oxidation-Reduction
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Rats
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Rats, Inbred Strains
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Starvation / metabolism
Substances
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Acetates
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Amino Acids
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Glutamates
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Aspartic Acid
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Glutamic Acid
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Dichloroacetic Acid
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Glucose
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Alanine