The neuroendocrine and behavioral response to dextroamphetamine in normal individuals

Biol Psychiatry. 1984 Sep;19(9):1305-15.


Dextroamphetamine 30 mg and placebo were administered by mouth in a double-blind randomized cross-over trial to ten subjects. Behavior was assessed and blood samples analyzed for growth hormone (GH), prolactin (PRL), homovanillic acid (HVA), and amphetamine. There was a statistically significant increase in well-being following d-amphetamine as compared to baseline and placebo on both the Amphetamine Interview Rating Scale and the Hopkins Mood Scale. No subject became psychotic. There was a statistically significant increase in GH from baseline to peak following d-amphetamine ingestion. When compared to placebo, the increase in GH was invariable and statistically significant for the 90-min sampling. PRL decreased from baseline following both d-amphetamine and placebo and there was no significant drug-placebo difference. Serum HVA was measured at baseline and 120 min, for eight subjects. Six subjects had an increase in HVA following d-amphetamine but there was no significant drug effect.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Affect / drug effects
  • Amphetamine / blood
  • Behavior / drug effects*
  • Brief Psychiatric Rating Scale
  • Dextroamphetamine / pharmacology*
  • Double-Blind Method
  • Female
  • Growth Hormone / blood*
  • Homovanillic Acid / blood*
  • Humans
  • Male
  • Phenylacetates / blood*
  • Prolactin / blood*
  • Random Allocation


  • Phenylacetates
  • Prolactin
  • Growth Hormone
  • Amphetamine
  • Dextroamphetamine
  • Homovanillic Acid