Human angiotensin I competes with two non-thiol converting enzyme inhibitors (CGS 13934 & MK-422) to inhibit the angiotensin-converting enzyme activity of human plasma

J Pharm Pharmacol. 1984 Oct;36(10):707-8. doi: 10.1111/j.2042-7158.1984.tb04853.x.

Abstract

A simple in-vitro enzyme system has been used to demonstrate that human angiotensin I interacts competitively with the two non-thiol converting enzyme inhibitors CGS 13934 and MK-422 to inhibit the hydrolysis of a synthetic substrate by human plasma ACE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin I / pharmacology*
  • Angiotensin-Converting Enzyme Inhibitors*
  • Angiotensins / pharmacology*
  • Dipeptides / pharmacology*
  • Enalaprilat
  • Female
  • Humans
  • In Vitro Techniques
  • Indoles / pharmacology*
  • Kinetics
  • Male
  • Peptidyl-Dipeptidase A / blood

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Angiotensins
  • Dipeptides
  • Indoles
  • pentoprilat
  • Angiotensin I
  • Peptidyl-Dipeptidase A
  • Enalaprilat