Abstract
20 women with stress incontinence were treated with an alpha-adrenoceptor stimulating agent norfenefrine (Nevadral Retard) for 3 months. The mean dose administered was 60 mg given in slow-release tablets. Significant beneficial effect on the symptom and the 'sign' of stress incontinence was found as well as a significant increase in the maximum urethral closure pressure. 7 patients (35%) became subjectively and objectively continent. Only minor side effects were observed during treatment.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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2-Hydroxyphenethylamine / administration & dosage
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2-Hydroxyphenethylamine / adverse effects
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2-Hydroxyphenethylamine / analogs & derivatives
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2-Hydroxyphenethylamine / therapeutic use*
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Adrenergic alpha-Agonists / therapeutic use*
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Adult
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Aged
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Delayed-Action Preparations
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Female
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Humans
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Male
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Middle Aged
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Octopamine* / analogs & derivatives*
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Phenethylamines / therapeutic use*
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Urethra / physiopathology
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Urinary Incontinence, Stress / drug therapy*
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Urinary Incontinence, Stress / physiopathology
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Urodynamics
Substances
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Adrenergic alpha-Agonists
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Delayed-Action Preparations
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Phenethylamines
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Octopamine
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2-Hydroxyphenethylamine
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norfenefrine