A double-blind study of the effect of trimipramine in patients with the irritable bowel syndrome

Scand J Gastroenterol. 1984 Sep;19(6):835-43.


The study was performed in 428 patients, of whom 216 were women. The median age was 36.5 (16-75) years and the median weight 67 (42-118) kg. The complaints were registered on a 10-cm-long linear analogue scale by the patients and the physicians. The patients were given coded identical-appearing tablets of placebo and different doses of trimipramine (Surmontil, Rhône-Poulenc) and randomized into groups A-E. During the 6 weeks of treatment the grades of complaints were reduced to about the half of pretreatment levels. The groups treated with trimipramine (groups A-D) felt significantly more improved than the group receiving placebo (group E). The side effect of tiredness was somewhat more pronounced 1-2 weeks after start with 50 mg trimipramine in the evening than in the groups receiving placebo and lower dose schedules of trimipramine.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anxiety / drug therapy
  • Clinical Trials as Topic
  • Colitis, Ulcerative / drug therapy*
  • Colitis, Ulcerative / psychology
  • Depression / drug therapy
  • Dibenzazepines / administration & dosage*
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Mental Fatigue / drug therapy
  • Middle Aged
  • Nausea / drug therapy
  • Sleep Wake Disorders / drug therapy
  • Trimipramine / administration & dosage*
  • Trimipramine / adverse effects
  • Vomiting / drug therapy


  • Dibenzazepines
  • Trimipramine