The antihypertensive effect of taurine in DOCA-salt rats

J Hypertens Suppl. 1984 Dec;2(3):S563-5.

Abstract

We studied the role of the sympathetic nervous system in the antihypertensive actions of taurine in DOCA (deoxycorticosterone acetate)-salt hypertensive rats. Supplementation with 1% taurine could moderate the development of the DOCA-salt hypertension. Norepinephrine turnover was measured from the rate of decline of tissue norepinephrine concentration after the administration of alpha-methyl-p-tyrosine. Cardiac and splenic norepinephrine turnover was markedly accelerated in the DOCA-salt rats compared with the vehicle-treated control rats, but the 1% taurine supplements could normalize this. These results suggest that the normalization of the increased sympathetic activity may be involved in the antihypertensive actions of taurine in DOCA-salt hypertensive rats.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antihypertensive Agents*
  • Blood Pressure / drug effects
  • Desoxycorticosterone / toxicity*
  • Drug Evaluation, Preclinical
  • Hypertension / chemically induced
  • Hypertension / drug therapy*
  • Hypertension / physiopathology
  • Male
  • Nephrectomy
  • Norepinephrine / metabolism
  • Rats
  • Rats, Inbred Strains
  • Sympathetic Nervous System / drug effects
  • Taurine / therapeutic use*
  • Tyrosine 3-Monooxygenase / antagonists & inhibitors

Substances

  • Antihypertensive Agents
  • Taurine
  • Desoxycorticosterone
  • Tyrosine 3-Monooxygenase
  • Norepinephrine