Abstract
The receptor-mediated endocytosis of alpha 2-macroglobulin can be inhibited by a diverse group of chemical compounds all of which share the property of being inhibitors of one form of cellular transglutaminase. The present results strongly suggest that protein cross-linking may be essential for receptor-mediated endocytosis of some protein and polypeptide hormones.
MeSH terms
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Amines / pharmacology
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Animals
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Cell Line
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Contact Inhibition
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Cricetinae
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Endocytosis* / drug effects
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Hormones / metabolism*
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Membrane Proteins / metabolism
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Peptides
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Rats
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Receptors, Drug / metabolism
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alpha-Macroglobulins / metabolism*
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gamma-Glutamyltransferase / antagonists & inhibitors
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gamma-Glutamyltransferase / metabolism*
Substances
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Amines
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Hormones
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Membrane Proteins
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Peptides
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Receptors, Drug
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alpha-Macroglobulins
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gamma-Glutamyltransferase