Establishment in continuous culture of a T-lymphoid cell line (HD-Mar) from a patient with Hodgkin's lymphoma

Int J Cancer. 1980 May 15;25(5):583-90. doi: 10.1002/ijc.2910250506.


A new cell line, HD-Mar, was established from a pleural effusion of a patient with Hodgkin's lymphoma. Formation of E rosettes, sensitivity to anti-T serum, elevated terminal deoxynucleotidyl transferase activity, presence of T-cell and the common ALL membrane antigens, morphology, and cytochemical staining indicate that the HD-Mar line is of thymic derivation. Absence of any immunoglobulin determinants, the lack of EBNA or any other EBV-associated antigen or function are also characteristics associated with established T-cell-derived lymphoma cell lines. Karyotype analysis indicated a tetraploid origin of the cell line.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, Viral
  • Cell Line
  • Chromosomes, Human
  • Complement C3
  • DNA Nucleotidylexotransferase / metabolism
  • Epitopes
  • Herpesvirus 4, Human / immunology
  • Hodgkin Disease / enzymology
  • Hodgkin Disease / immunology
  • Hodgkin Disease / pathology*
  • Humans
  • Immunoglobulin Fc Fragments / analysis
  • Male
  • Microscopy, Electron, Scanning
  • Pleural Effusion / cytology
  • Receptors, Antigen, B-Cell / analysis
  • Receptors, Complement / analysis
  • Receptors, Virus / analysis
  • Rosette Formation
  • T-Lymphocytes / immunology
  • T-Lymphocytes / ultrastructure


  • Antigens, Viral
  • Complement C3
  • Epitopes
  • Immunoglobulin Fc Fragments
  • Receptors, Antigen, B-Cell
  • Receptors, Complement
  • Receptors, Virus
  • DNA Nucleotidylexotransferase