Chemotherapy of disseminated seminoma

Cancer Clin Trials. 1980;3(4):307-13.

Abstract

Nineteen patients with disseminated seminoma were treated with platinum + vinblastine + bleomycin +/- Adriamycin. All patients have been followed for at least 1 year. Nine patients had elevated HCG and two also had elevated AFP. Twelve of 19 patients (63%) achieved a complete remission, with a median duration of 18 months, and none of these patients have relapsed. Four of these patients have been in a continuous complete remission for over 2 years. The results of chemotherapy in metastatic seminoma are comparable to those achieved in nonseminomatous germ-cell tumors, and similar treatment strategies should be employed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Antineoplastic Agents / administration & dosage*
  • Bleomycin / administration & dosage
  • Chorionic Gonadotropin / blood
  • Cisplatin / administration & dosage
  • Doxorubicin / administration & dosage
  • Drug Therapy, Combination
  • Dysgerminoma / blood
  • Dysgerminoma / drug therapy*
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Testicular Neoplasms / blood
  • Testicular Neoplasms / drug therapy*
  • Vinblastine / administration & dosage
  • alpha-Fetoproteins / analysis

Substances

  • Antineoplastic Agents
  • Chorionic Gonadotropin
  • alpha-Fetoproteins
  • Bleomycin
  • Vinblastine
  • Doxorubicin
  • Cisplatin