Controlled clinical trial of four short-course regimens of chemotherapy for two durations in the treatment of pulmonary tuberculosis. Second report. Third East African/British Medical Research Council Study

Tubercle. 1980 Jun;61(2):59-69. doi: 10.1016/0041-3879(80)90012-4.


Four short-course chemotherapy regimens for pulmonary tuberculosis have been compared: (1) streptomycin, isoniazid, rifampicin and pyrazinamide daily for 2 months followed by daily thiacetazone plus isoniazid; (2) the same 4 drugs daily for 1 month followed by thiacetazone plus isoniazid; (3) the same 4 drugs daily for 1 month followed by twice-weekly streptomycin, isoniazid and pyrazinamide; (4) the first regimen but without pyrazinamide in the initial intensive phase. Each regimen was given for 6 and 8 months and patients were followed up to 30 months. When given for 6 months the regimen with a 2-month 4-drug intensive phase had a bacteriological relapse rate of 13% and when given for 8 months there were no relapses. When pyrazinamide was omitted in the first 2 months the relapse rates were 18% for the 6-month and 6% for the 8-month series. The regimen with the 4-drug initial phase shortened to 1 month had relapse rates of 18% and 7% respectively if the continuation phase was thiacetazone plus isoniazid. However, the relapse rates were lower, 9% and 2% respectively, when the continuation phase was twice-weekly streptomycin, isoniazid and pyrazinamide.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Antibiotics, Antitubercular / administration & dosage*
  • Clinical Trials as Topic
  • Drug Administration Schedule
  • Drug Resistance, Microbial
  • Drug Therapy, Combination
  • Humans
  • Isoniazid / administration & dosage
  • Pyrazinamide / administration & dosage
  • Random Allocation
  • Rifampin / administration & dosage
  • Streptomycin / administration & dosage
  • Thioacetazone / administration & dosage
  • Time Factors
  • Tuberculosis, Pulmonary / drug therapy*


  • Antibiotics, Antitubercular
  • Pyrazinamide
  • Thioacetazone
  • Isoniazid
  • Rifampin
  • Streptomycin