N4-hydroxycytidine: a mutagen specific for AT to GC transitions

Mutat Res. 1980 Aug;72(1):43-7. doi: 10.1016/0027-5107(80)90218-3.

Abstract

N4-Hydroxycytidine is a mutagen of the base-analog type and one of the products formed by treatment of cytidine with hydroxylamine. In this communication evidence is presented showing that, in contrast with other known base analogs, N4-hydroxycytidine results mainly, if not exclusively, in AT leads to GC transitional alterations in Escherichia coli K12.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cytidine / analogs & derivatives*
  • Cytidine / pharmacology
  • DNA Repair
  • DNA, Bacterial / biosynthesis
  • DNA-Directed DNA Polymerase / metabolism
  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Lac Operon / drug effects
  • Mutagens*
  • RNA Polymerase I / metabolism
  • RNA, Bacterial / biosynthesis
  • Substrate Specificity

Substances

  • DNA, Bacterial
  • Mutagens
  • RNA, Bacterial
  • Cytidine
  • N(4)-hydroxycytidine
  • RNA Polymerase I
  • DNA-Directed DNA Polymerase