Angiogenesis in vitro

Nature. 1980 Dec 11;288(5791):551-6. doi: 10.1038/288551a0.


Cloned capillary endothelial cells, cultured in tumour-conditioned medium, form capillary tubes. By light and electron microscopy these tubes resemble capillaries in vivo. This first demonstration of angiogenesis in vitro: (1) shows that all the information necessary to develop an entire capillary network in vitro is expressed by one cell type; (2) suggests a mechanism for lumen formation; and (3) offers a possibility of distinguishing between direct and indirect angiogenesis factors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Angiogenesis Inducing Agents / analysis
  • Capillaries / growth & development*
  • Capillaries / ultrastructure
  • Cell Aggregation
  • Cells, Cultured
  • Endothelium / physiology*
  • Microscopy, Electron
  • Neovascularization, Pathologic*
  • Vacuoles / ultrastructure


  • Angiogenesis Inducing Agents