Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation

Nature. 1981 Jan 29;289(5796):373-8. doi: 10.1038/289373a0.


Four 'antigenic sites' on the three-dimensional structure of the influenza haemagglutinin are identified. At least one amino acid substitution in each site seems to be required for the production of new epidemic strains between 1968 and 1975.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigen-Antibody Reactions
  • Binding Sites
  • Epitopes
  • Glycoproteins / immunology*
  • Hemagglutinins, Viral / immunology*
  • Influenza A virus / immunology*
  • Membrane Proteins / immunology*
  • Protein Conformation
  • Viral Proteins / immunology*


  • Epitopes
  • Glycoproteins
  • Hemagglutinins, Viral
  • Membrane Proteins
  • Viral Proteins