In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas

Cancer Biochem Biophys. 1977;2(2):51-4.


Cannabinoids represent a novel class of drugs active in increasing the life span mice carrying Lewis lung tumors and decreasing primary tumor size. In the present studies, the effects of delta9-THC, delta8-THC, and cannabidiol on tumor macromolecular biosynthesis were studied. These drugs inhibit thymidine-3H incorporation into DNA acutely, but did not inhibit leucine uptake into tumor protein. At 24 h after treatment, cannabinoids did not inhibit thymidine-3H incorporation into DNA, leucine-3H uptake into protein or cytidine-3H into RNA.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cannabidiol / pharmacology
  • Cannabinoids / pharmacology*
  • DNA, Neoplasm / biosynthesis*
  • Dronabinol / pharmacology
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Neoplasm Proteins / biosynthesis*
  • Neoplasms, Experimental / drug therapy
  • RNA, Neoplasm / biosynthesis*
  • Tissue Distribution


  • Cannabinoids
  • DNA, Neoplasm
  • Neoplasm Proteins
  • RNA, Neoplasm
  • Cannabidiol
  • Dronabinol