Abstract
Vesicular stomatitis virus (VSV) infection of beige (bg/bg) mice induced levels of natural killer cytolytic activity comparable to that of uninfected normal bg/+ controls, but considerably less than natural killer activity in VSV-infected bg/+ mice. In contrast, VSV-infected bg/bg and bg/+ mice had essentially equivalent amounts of anti-VSV cytotoxic T-lymphocyte and antibody activity. VSV infection induced comparable levels of interferon in both bg/bg and bg/+ mice. Therefore, the decreased natural killer activity in bg/bg mice could not be attributed to an inability to produce interferon.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Viral / biosynthesis
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Antilymphocyte Serum / pharmacology
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Cytotoxicity, Immunologic
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Female
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Guinea Pigs
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H-2 Antigens / immunology
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Interferons / biosynthesis
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Killer Cells, Natural / immunology
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Killer Cells, Natural / microbiology*
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Lymphoma / immunology
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Male
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Mice
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Mice, Inbred C57BL
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Stomatitis / immunology
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Stomatitis / microbiology*
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Vesicular stomatitis Indiana virus / immunology
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Virus Diseases / immunology
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Virus Diseases / microbiology*
Substances
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Antibodies, Viral
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Antilymphocyte Serum
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H-2 Antigens
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Interferons