Cortical projections to the periaqueductal gray in the monkey: a retrograde and orthograde horseradish peroxidase study

Neurosci Lett. 1981 Mar 10;22(2):97-101. doi: 10.1016/0304-3940(81)90070-7.


Stereotaxic fluid microinjections of horseradish peroxidase (HRP) into the periaqueductal gray (PAG), coupled with cortical HRP gel placements in macaque and cebus monkeys, have provided substantive retrograde and orthograde evidence that the rostral dorsal convexity and rostral medial prefrontal cortex are the principal sources of cortical-PAG projections. The prefrontal cortex projects to the dorsolateral quadrant of the PAG, precisely the area shown to receive spinothalamic inputs in mammals, including monkey. The findings are discussed in terms of a possible affective role in central analgesic mechanisms.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Afferent Pathways / physiology*
  • Animals
  • Axonal Transport
  • Brain / physiology*
  • Cebus
  • Cerebral Cortex / physiology*
  • Efferent Pathways / physiology*
  • Horseradish Peroxidase
  • Macaca fascicularis


  • Horseradish Peroxidase