Association of minimal change nephrotic syndrome (MCNS) with HLA-B8 an B13

Clin Nephrol. 1981 Apr;15(4):172-4.

Abstract

HLA antigens of 45 children with idiopathic nephrotic syndrome were typed for 26 phenotypic specificities. A significant association of MCNS with HLA-B 8 and B 13 was found. There was also a significantly increased frequency of the antigen combination HLA-A 1/B 8 (most presumably the haplo-type). The association with HLA-B 8 provides further evidence of an important role of immune mechanisms in the pathogenesis of MCNS.

MeSH terms

  • Child
  • Epitopes / immunology
  • HLA Antigens / immunology*
  • HLA-B Antigens
  • Humans
  • Nephrotic Syndrome / immunology*

Substances

  • Epitopes
  • HLA Antigens
  • HLA-B Antigens