The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

Eur J Immunol. 1981 Mar;11(3):195-9. doi: 10.1002/eji.1830110307.


The isolation and propagation of functional antigen-specific lines of T lymphoblasts is described. These lines were found to recognize foreign or self antigens in association with accessory cells of syngeneic major histocompatibility complex genotype. Intravenous inoculation of a T cell reactive only against myelin basic protein led to development of clinical paralysis in syngeneic rats. Thus, it is possible to study biological function as well as antigen specificity using T cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Clone Cells / immunology*
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Epitopes
  • Major Histocompatibility Complex
  • Rats
  • T-Lymphocytes / immunology*


  • Epitopes