Protein synthesis in liver and small intestine in protein deprivation and diabetes

Am J Physiol. 1981 Sep;241(3):E238-45. doi: 10.1152/ajpendo.1981.241.3.E238.


Protein synthesis (as a percent of the protein pool synthesized per day) has been measured in liver and small intestine of young male rats from the incorporation of 100 mumol [1-14C]leucine/100 g body wt into protein over 10 min. Dietary protein deprivation for 8 days depressed protein synthesis in liver (30%), jejunal mucosa (20%), and jejunal serosa (25%). In serosa, reduced levels of RNA relative to protein could account for altered synthesis; in liver and mucosa, the amount of protein synthesized per unit RNA was reduced. In liver of streptozotocin-diabetic rats protein synthesis was depressed 45%, whereas it was maintained in jejunal mucosa and serosa. Depressed synthesis in liver was accompanied by both a loss of RNA relative to protein and a reduction in the protein synthesized per RNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Weight
  • DNA / biosynthesis
  • Diabetes Mellitus, Experimental / metabolism*
  • Intestinal Mucosa / metabolism
  • Jejunum / metabolism*
  • Kinetics
  • Liver / metabolism*
  • Male
  • Organ Size
  • Protein Biosynthesis*
  • Protein-Energy Malnutrition / metabolism*
  • RNA / biosynthesis
  • Rats
  • Rats, Inbred Strains


  • RNA
  • DNA