A comparative study of eight cell lines derived from human testicular teratocarcinoma

Int J Cancer. 1980 Sep 15;26(3):269-80. doi: 10.1002/ijc.2910260304.


Eight independent cell lines, derived from human testicular germ-cell tumors, were examined for the expression of various markers. These included major histocompatibility and embryonic antigens, chorionic gonadotropin, alpha fetoprotein, alkaline phosphatase, plasminogen activator, and infectivity by SV40. No line consisted primarily of choriocarcinoma or yolk sac cells, but several contained cells resembling murine embryonal carcinoma; some of these lines formed tumors with the distinctive features of embryonal carcinoma when injected into immunosuppressed animals. It is proposed that human embryonal carcinoma cells, unlike those of the mouse, correspond to a preblastocyst stage of development.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkaline Phosphatase / analysis
  • Animals
  • Antigens, Neoplasm / analysis
  • Cell Line
  • Chorionic Gonadotropin / biosynthesis
  • Humans
  • L-Lactate Dehydrogenase / analysis
  • Male
  • Mice
  • Neoplasm Transplantation
  • Teratoma / analysis
  • Teratoma / immunology
  • Teratoma / pathology*
  • Testicular Neoplasms / analysis
  • Testicular Neoplasms / immunology
  • Testicular Neoplasms / pathology*
  • Transplantation, Heterologous
  • Virus Replication
  • alpha-Fetoproteins / biosynthesis


  • Antigens, Neoplasm
  • Chorionic Gonadotropin
  • alpha-Fetoproteins
  • L-Lactate Dehydrogenase
  • Alkaline Phosphatase