Biochemical controls of liver cholesterol biosynthesis

Am J Clin Nutr. 1981 Oct;34(10):2295-306. doi: 10.1093/ajcn/34.10.2295.

Abstract

Major endogenous regulatory controls of cholesterol synthesis including dietary-feedback inhibition, circadian rhythms, feeding/fasting fluctuations, and enterohepatic bile acid circulation are discussed in terms of biochemical control mechanisms of liver cholesterol biosynthesis. Other likely control mechanisms such as cofactors, enzyme levels, and enzyme activities are noted. The current state of the biochemical knowledge is very dependent upon integrated data from one experimental animal - the rat. Inferences and implications in the human are thus limited.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetates / metabolism
  • Acetyl Coenzyme A / metabolism
  • Acyl Coenzyme A / metabolism
  • Allosteric Regulation / drug effects
  • Animals
  • Bile Acids and Salts / physiology
  • Cells, Cultured
  • Cholesterol / biosynthesis*
  • Cholesterol, Dietary / pharmacology
  • Circadian Rhythm
  • Diet
  • Diphosphates / metabolism
  • Enterohepatic Circulation
  • Fasting
  • Feedback
  • Female
  • Food
  • Humans
  • Hydroxymethylglutaryl CoA Reductases / metabolism
  • Lipoproteins, LDL / pharmacology
  • Liver / enzymology
  • Liver / metabolism*
  • Male
  • Meglutol / analogs & derivatives
  • Meglutol / metabolism
  • Mevalonic Acid / metabolism
  • Rats
  • Receptors, Cell Surface / metabolism
  • Receptors, LDL
  • Squalene / metabolism
  • Tretinoin / pharmacology

Substances

  • Acetates
  • Acyl Coenzyme A
  • Bile Acids and Salts
  • Cholesterol, Dietary
  • Diphosphates
  • Lipoproteins, LDL
  • Receptors, Cell Surface
  • Receptors, LDL
  • 3-hydroxy-3-methylglutaryl-coenzyme A
  • Tretinoin
  • Acetyl Coenzyme A
  • Squalene
  • Cholesterol
  • Meglutol
  • Hydroxymethylglutaryl CoA Reductases
  • Mevalonic Acid