Abstract
Thiamphenicol, rifampicin, amantadine, cytosine arabinoside and isoprinosine were administered to mice which were inoculated with brain tissue containing Creutzfeldt-Jakob disease (CJD). All the mice developed disease within 3 to 6 months after inoculation. As there was no significant shift in incubation periods among animal groups of each drug administration and non-administration, these compounds had no effect in controlling experimental CJD.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amantadine / therapeutic use
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Animals
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Anti-Bacterial Agents / therapeutic use*
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Antiviral Agents / therapeutic use*
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Creutzfeldt-Jakob Syndrome / drug therapy*
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Cytarabine / therapeutic use
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Humans
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Inosine Pranobex / therapeutic use
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Mice
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Mice, Inbred C57BL
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Mice, Inbred Strains
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Rifampin / therapeutic use
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Thiamphenicol / therapeutic use
Substances
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Anti-Bacterial Agents
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Antiviral Agents
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Cytarabine
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Amantadine
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Thiamphenicol
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Rifampin
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Inosine Pranobex