Partial splenic embolization using polyvinyl alcohol foam, dextran, polystyrene, or silicone. An experimental study in dogs

Radiology. 1982 Feb;142(2):351-4. doi: 10.1148/radiology.142.2.6172809.

Abstract

Partial splenic arterial embolization (50% reduction in flow) was evaluated in dogs using polyvinyl alcohol foam or microspheres (20-500 mu) made of dextran, polystyrene, or silicone. Dextran and polystyrene were found to be superior for several reasons: they were easier to use, did not shatter when agitated, and produced permanent, homogeneous, peripheral occlusion with only one administration. Partial embolization with dextran or polystyrene increased platelet levels within 1 week and markedly reduced splenic size with minimal if any collateral filling within 6 weeks. Microscopically, no acute infarction or necrosis was seen at 6 weeks; there was some fibrosis, but the remaining parenchyma appeared normal.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anion Exchange Resins*
  • Dextrans*
  • Dogs
  • Embolization, Therapeutic*
  • Gels*
  • Hypersplenism / therapy
  • Ion Exchange Resins*
  • Microspheres
  • Platelet Count
  • Polyvinyls*
  • Resins, Synthetic
  • Silicones*
  • Splenic Artery*

Substances

  • Anion Exchange Resins
  • Dextrans
  • Gels
  • Ion Exchange Resins
  • Polyvinyls
  • Resins, Synthetic
  • Silicones
  • ivalon sponge
  • dextranomer
  • Dowex
  • sephadex