Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells

Nature. 1982 Jan 14;295(5845):116-9. doi: 10.1038/295116a0.

Abstract

Polyadenylated RNAs of certain human tumour cell lines are shown to contain transcripts related to the cell-derived transforming onc genes of molecularly cloned primate, murine or avian transforming retrovirus genomes. Thus, analogues of retroviral transforming genes are both present and frequently expressed in human neoplastic cells.

MeSH terms

  • Base Sequence
  • Cell Line
  • Cell Transformation, Viral
  • Female
  • Genes, Viral*
  • Glioblastoma
  • Humans
  • Melanoma
  • Neoplasms / genetics*
  • Poly A / genetics*
  • Protein Biosynthesis
  • RNA / genetics*
  • RNA, Messenger
  • Retroviridae / genetics*
  • Sarcoma
  • Teratoma
  • Transcription, Genetic*

Substances

  • RNA, Messenger
  • Poly A
  • RNA