Effect of salbutamol on the cerebral levels, uptake and turnover of serotonin

Eur J Pharmacol. 1982 Mar 12;78(3):357-61. doi: 10.1016/0014-2999(82)90038-3.


The effect of salbutamol (SB) on the cerebral levels of serotonin (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) was determined as well as the effect on the uptake and turnover of 5-HT in rat brain. SB failed to inhibit the cerebral uptake of 5-HT and did not change 5-HT and 5-HIAA levels in the brain; however, it significantly increased the cerebral turnover of 5-HT. The latter effect may partly be responsible for the antidepressant properties of the compounds.

MeSH terms

  • Albuterol / pharmacology*
  • Animals
  • Brain / drug effects
  • Brain / metabolism*
  • Drug Interactions
  • Hydroxyindoleacetic Acid / metabolism
  • In Vitro Techniques
  • Male
  • Pargyline / pharmacology
  • Probenecid / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Serotonin / metabolism*
  • Synaptosomes / metabolism
  • p-Chloroamphetamine / pharmacology


  • Serotonin
  • Hydroxyindoleacetic Acid
  • p-Chloroamphetamine
  • Pargyline
  • Probenecid
  • Albuterol