Persistent cerebellar ataxia after exposure to toluene

Ann Neurol. 1977 Nov;2(5):440-2. doi: 10.1002/ana.410020518.


An optometrist and a glue sniffer exposed independently to toluene vapors developed cerebellar, pyramidal, and cognitive dysfunction. All deficits cleared completely in the former but persisted in the latter. The findings confirm a previous report of a toluene-induced neurological syndrome that is exclusively central, sparing peripheral nerves.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cerebellar Ataxia / chemically induced*
  • Cerebellar Ataxia / diagnostic imaging
  • Environmental Exposure
  • Humans
  • Hydrocephalus / chemically induced
  • Hydrocephalus / diagnostic imaging
  • Male
  • Middle Aged
  • Occupational Diseases / chemically induced*
  • Occupational Diseases / diagnostic imaging
  • Optometry
  • Substance-Related Disorders / complications*
  • Toluene / poisoning*
  • Tomography, X-Ray Computed


  • Toluene