Quantitated determination of proteins in perilymph in patients with acoustic neuromas

ORL J Otorhinolaryngol Relat Spec. 1982;44(2):61-5. doi: 10.1159/000275574.


Perilymph, cerebrospinal fluid (CSF) and plasma from 19 patients with acoustic neuromas were examined for albumin, alpha 2-macroglobulin and IgG. Patients with otosclerosis were used as controls. A highly significant increase of the tested proteins was found in perilymph from patients with acoustic neuromas. Determination of the tau-transferrin, which is a specific CNS protein, could neither be demonstrated in plasma nor in perilymph. This is in favour of the assumption that perilymph is plasma-derived and not concentrated CSF. Various causes for the high protein concentrations are discussed, and it is suggested that the increase is caused by a blockage of the neuroaxonal transport mechanisms.

MeSH terms

  • Adult
  • Aged
  • Albumins / analysis
  • Female
  • Humans
  • Immunoglobulin G / analysis
  • Labyrinthine Fluids / analysis*
  • Male
  • Middle Aged
  • Neuroma, Acoustic / analysis*
  • Perilymph / analysis*
  • Proteins / analysis*
  • Transferrin / analysis
  • alpha-Macroglobulins / analysis
  • tau Proteins


  • Albumins
  • Immunoglobulin G
  • Proteins
  • Transferrin
  • alpha-Macroglobulins
  • tau Proteins