Abstract
Vasoactive intestinal peptide caused a prompt, dose-dependent relaxation of isolated gastric smooth muscle cells of the guinea pig and a significant increase in intracellular adenosine 3',5'-monophosphate coincidentally with optimum relaxation. Relaxation was augmented by a threshold concentration of isobutyl methylxanthine. The direct relaxant effect of vasoactive intestinal peptide and the distribution of nerves containing this peptide to circular smooth muscle support the view that vasoactive intestinal peptide is the neuromuscular transmitter of enteric inhibitory nerves.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
1-Methyl-3-isobutylxanthine / pharmacology
-
Animals
-
Cyclic AMP / physiology
-
Gastrointestinal Hormones / pharmacology*
-
Guinea Pigs
-
In Vitro Techniques
-
Muscle Contraction / drug effects*
-
Muscle Relaxation / drug effects*
-
Muscle, Smooth / drug effects*
-
Neurotransmitter Agents / physiology
-
Stomach / drug effects
-
Stomach / innervation*
-
Vasoactive Intestinal Peptide / pharmacology*
Substances
-
Gastrointestinal Hormones
-
Neurotransmitter Agents
-
Vasoactive Intestinal Peptide
-
Cyclic AMP
-
1-Methyl-3-isobutylxanthine