Hemangioblastomas: histogenesis of the stromal cell studied by immunocytochemistry

Hum Pathol. 1982 Jan;13(1):13-8. doi: 10.1016/s0046-8177(82)80133-0.


Twenty-one cases of hemangioblastoma from the cerebellum, spinal cord and retina were studied using the unlabeled antibody peroxidase-antiperoxidase technique with antibodies directed against glial fibrillary acidic protein (GFAP) and factor VIII related antigen (VIIIR:Ag). In 19 of 21 cases studied with anti-GFAP, astrocytes were identified peripherally, and in 13 cases they were found centrally within the tumor. In no instance did stromal cells react positively for GFAP. Sixteen cases with anti-VIIIR:Ag antibody were examined, and in all cases many stromal cells showed positive staining. It is concluded that the stromal cells were of endothelial origin. The occasional stromal cells that other investigators have identified as reacting positively for GFAP may represent stromal cells capable of ingesting extracellular GFAP derived from reactive astrocytes within the tumor, or they may be lipidized astrocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens / analysis*
  • Astrocytes / analysis
  • Cerebellar Neoplasms / immunology
  • Cerebellar Neoplasms / pathology
  • Endothelium / pathology
  • Eye Neoplasms / immunology
  • Eye Neoplasms / pathology
  • Factor VIII / analysis
  • Factor VIII / immunology*
  • Glial Fibrillary Acidic Protein
  • Hemangiosarcoma / immunology
  • Hemangiosarcoma / pathology*
  • Humans
  • Immunoenzyme Techniques
  • Nerve Tissue Proteins / analysis*
  • Spinal Cord Neoplasms / immunology
  • Spinal Cord Neoplasms / pathology
  • Staining and Labeling
  • von Willebrand Factor


  • Antigens
  • Glial Fibrillary Acidic Protein
  • Nerve Tissue Proteins
  • von Willebrand Factor
  • Factor VIII