Abstract
Medial histocompatibility (H) antigens are weak H antigens, recognized by unrestricted T cells; they differ thus from both major and minor H antigens. An example, Qed-1, is described in detail, and other known medial H antigens of the mouse are reviewed. The structural and genetic relationships of major and medial H antigens and their role in T cell recognition are discussed.
MeSH terms
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Animals
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Antigens, T-Independent / genetics*
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Epitopes / genetics
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Genes
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Genetic Linkage
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Graft Rejection
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H-2 Antigens / genetics
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Histocompatibility Antigens Class II / genetics
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Humans
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Major Histocompatibility Complex
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Mice
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Rats
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Skin Transplantation
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T-Lymphocytes / immunology*
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Tissue Distribution
Substances
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Antigens, T-Independent
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Epitopes
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H-2 Antigens
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Histocompatibility Antigens Class II