Infants with bronchopulmonary dysplasia. Growth pattern and neurologic and developmental outcome

Am J Dis Child. 1982 May;136(5):443-7. doi: 10.1001/archpedi.1982.03970410061015.


We evaluate neurodevelopmental and growth outcomes of low-birth-weight infants with bronchopulmonary dysplasia (BPD). Twenty-six cases of BPD (group A) were diagnosed from 244 neonatal survivors with a low birth weight (less than or equal to 1,500 g) born in 1975, 1976, and 1977. During the same period, BPD did not develop in eight infants with a comparable neonatal course (group B) (received oxygen therapy greater than or equal to 21 days). Twenty-five infants who received O2 therapy five or fewer days had a mild clinical course and were considered controls (group C). The BPD infants suffered more asphyxia, respiratory distress syndrome, acidosis, and longer parenteral alimentation and hospitalization than group C infants. Compared with groups B and C, the BPD infants had more respiratory morbidities at 4 and 12 months (P less than .005) and more severe neurodevelopmental sequelae at 2 years.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bronchopulmonary Dysplasia / complications*
  • Central Nervous System Diseases / etiology
  • Child, Preschool
  • Developmental Disabilities / etiology*
  • Growth Disorders / etiology
  • Humans
  • Infant
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Oxygen Inhalation Therapy / adverse effects
  • Prospective Studies
  • Respiratory Tract Infections / etiology*