Long-term follow-up of patients with subacute sclerosing panencephalitis treated with inosiplex

Ann Neurol. 1982 Apr;11(4):359-64. doi: 10.1002/ana.410110407.


During the past five years, 15 patients with subacute sclerosing panencephalitis (SSPE) were treated with inosiplex. Using a disability index specifically designed for the disease, this study monitored the course of SSPE in each patient before and during inosiplex therapy. Posttreatment follow-up ranged from 2 to 144 months. Inosiplex had an apparently beneficial effect on morbidity and mortality in 10 of the 15 patients tested. Eight improved immediately after treatment, 2 had a delayed improvement, and 1 patient stabilized. Four patients followed a typical course for SSPE and died a mean 9 months after onset. Treatment was not associated with adverse reactions. Due to its low risk-benefit ratio, inosiplex is recommended for continuous use in SSPE even after extended remissions.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Female
  • Follow-Up Studies
  • Humans
  • Inosine / analogs & derivatives*
  • Inosine Pranobex / therapeutic use*
  • Male
  • Measles / complications
  • Neurologic Examination
  • Subacute Sclerosing Panencephalitis / drug therapy*


  • Inosine
  • Inosine Pranobex