Palliative treatment of tardive dyskinesia with combination of amantadine-neuroleptic administration

Biol Psychiatry. 1982 Jun;17(6):719-27.


The author presents six cases which suggest a palliative effect of combination amantadine/neuroleptic in tardive dyskinesia. The six patients all met criteria for definite tardive dyskinesia, and did not have coexistent pseudoparkinsonism. Serial addition and subtraction of amantadine with fixed low-dose neuroleptic points to a specific amantadine effect. Previous studies are reviewed and speculation about the mechanism of action of the combination is discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Amantadine / therapeutic use*
  • Antipsychotic Agents / adverse effects
  • Dementia / drug therapy
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Dyskinesia, Drug-Induced / drug therapy*
  • Female
  • Haloperidol / therapeutic use
  • Humans
  • Male
  • Middle Aged
  • Neurocognitive Disorders / drug therapy*
  • Palliative Care / methods*
  • Schizophrenia / drug therapy*
  • Schizophrenia, Paranoid / drug therapy
  • Thioridazine / therapeutic use


  • Antipsychotic Agents
  • Amantadine
  • Haloperidol
  • Thioridazine