Structure of the human immune interferon gene

Nature. 1982 Aug 26;298(5877):859-63. doi: 10.1038/298859a0.


Sequence determination of cloned cDNAs and genes of the three classes of interferon (IFN-alpha, -beta and -gamma) has revealed more than a dozen members of the human IFN-alpha gene family and a single gene for IFN-beta. These genes are found on chromosome 9 and contain no introns. We recently reported that the 146-amino acid sequence of mature IFN-gamma deduced from the nucleotide sequence of a cloned cDNA was quite unrelated to those of the other IFNs, and that the gene for IFN-gamma contains at least one intron. We now describe the isolation, characterization and DNA sequence of the human IFN-gamma gene. It contains three introns, a repetitive DNA element, and is not highly polymorphic. All our evidence to date and the present data suggest that this is the only gene for IFN-gamma and that the resolution of IFN-gamma into two components is probably the result of post-translational processing of the protein.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • DNA / genetics
  • DNA Restriction Enzymes
  • DNA, Recombinant
  • Genes
  • Humans
  • Interferons / analysis
  • Interferons / genetics*
  • Interferons / metabolism
  • Nucleic Acid Hybridization
  • Repetitive Sequences, Nucleic Acid


  • DNA, Recombinant
  • DNA
  • Interferons
  • DNA Restriction Enzymes

Associated data

  • GENBANK/J00219